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Image Search Results
Journal: bioRxiv
Article Title: Radiation-induced persistent DNA damage response and late toxicity in cardiac tissue
doi: 10.1101/2023.02.27.530210
Figure Lengend Snippet: (A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which ECG were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Article Snippet: An
Techniques: Irradiation