labchart 8 (ecg analysis, blood pressure modules) toolbox Search Results


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ADInstruments labchart 8
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Ecg Analysis Module, supplied by ADInstruments, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Labchart 8 Hrv, supplied by ADInstruments, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Personal Computer Based Acquisition System Labchart 8.0, supplied by POWERLAB INC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Powerlab System, supplied by ADInstruments, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Ecg Signals, supplied by ADInstruments, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which <t>ECG</t> were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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Image Search Results


(A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which ECG were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Journal: bioRxiv

Article Title: Radiation-induced persistent DNA damage response and late toxicity in cardiac tissue

doi: 10.1101/2023.02.27.530210

Figure Lengend Snippet: (A) Schematic representation of the experimental design for cardiac irradiation of A/J mice. Three to five mice were given mock, 13 Gy or 15 Gy targeted RT to the heart, six months after which ECG were acquired and mice were euthanised for analysis of heart tissue. (B) Representative 1.0-second-long ECG traces acquired from A/J mice 26 weeks after mock and 15 Gy RT. One of six mice in the 15 Gy cardiac irradiated and two of six mice in the 13 Gy thorax irradiated mice developed arrhythmia six months after RT. (C) Heart rate variability was measured by root mean square of successive RR interval differences (RMSSD) of mock, 13 Gy or 15 Gy heart irradiated mice. Each data point represents the mean RMSSD calculated from analysis of ECG traces of more than 100 successive heartbeats. (D) Mean QTc, QRS, and PR lengths and ST height calculated from an ECG analysis of more than 100 successive heartbeats acquired from mock, 13 Gy or 15 Gy RT mice. (E) Heart weights of mock, 13 Gy or 15 Gy heart RT mice normalised to whole-body weights. Data points indicating mice with the highest heart weights are shown in empty circles. (F) Pictures of transverse cross-sections of formalin-fixed hearts of mock RT mice (top panel) and 15 Gy RT mice with the highest body weights (bottom panel) shown. Enlarged right ventricles are indicated in white arrows. Results are mean ± SEM, analysed by a one-way ANOVA test. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Article Snippet: An ECG analysis module (LabChart 8, ADInstruments) was applied with mouse ECG trace settings (4 beats averaging; pre-P baseline of 10ms, maximum PR of 50 ms and maximum RT of 40 ms) for segmentation of ECG waveforms to identify P-wave, QRS complex and T-waves.

Techniques: Irradiation